Based on a review by Schins et al. (54), the increased risk of thromboembolic events in patients with depression and cardiovascular disease may be linked to the upregulation and/or heightened sensitivity of serotonin receptors 5-HT2A/1B, as well as the downregulation of serotonin transporter (5-HTT) receptors. This evidence concerns the gene HTR2A and major depressive disorder.