Taken together, while it is still unclear whether poor PFC functioning is the cause of low tonic DA activation in the striatum, and what role DAT activity plays in this, or whether increased phasic striatal output causes poor PFC functioning, it is clear that this PFC DA circuitry plays a prominent role in ADHD-related behavioral deficits (80). The gene discussed is SLC6A3; the disease is attention deficit-hyperactivity disorder.