XPNPEP3 and acute kidney injury: Strikingly, with the application of cisplatin (CDDP) to simulate mouse models of acute kidney injury (AKI), XPNPEP3−/−CDDP-AKI mice had obvious tubular dilation in HE staining and fibrosis in Masson staining compared with WT-CDDP-AKI mice (Figure 6B).