Compound 54 shows an IC50 of54 nM for METTL3/METTL14 in the HTRF assay, selectivity against theoff-targets METTL1 and METTL16, and a GI50 of 6 μMfor the MOLM-13 AML cell line. Here, METTL1 is linked to acute myeloid leukemia.