HK2 and cancer: Insulin-like growth factor mRNA binding protein 3 (IMP3) is an RBP that regulates glycolysis levels in cancer cells and binds to 3’UTR of HK2 mRNA, which can be weakened by knocking down circCDKN2B-AS1; therefore, the stability of HK2 mRNA would be destroyed, the expression of HK2 declines and glycolysis in cervical cancer cells is inhibited [27].