NLRP3 pathway inhibition avoids adipose tissue inflammation and diminishes obesity and related metabolic disorders [49], and the use of natural compounds with antioxidant capacity, such as polyphenols or carotenoids, has been described as having beneficial effects in the control of diabetic complications through NLRP3 pathway control [56–60]. This evidence concerns the gene NLRP3 and obesity due to melanocortin 4 receptor deficiency.