Moreover, enrichment of pathways such as epithelial to mesenchymal transition mediated by INV-H specific MRs: NOTCH3, NOTCH4, ZEB1, ZEB2, TGFB1, TGFB2, and extracellular matrix organization, ECM proteoglycans through activation of MRs: DCN, TGFB1, TGFB2, ITGB2, ITGA3, ACTN1, and ICAM1 are hallmarks of cancer metastasis [68] and stemness [69] respectively. The gene discussed is NOTCH4; the disease is cancer.