CD28 and cancer: Its high activation in INV-H samples of the ten prognostic cancers, along with enrichment of T-cell receptor (TCR) signaling and selective expression of chemokine receptors during T-cell polarization (involving MRs: CD4, CD28, TGFB1, and TGFB2) suggests the occurrence of the phenomenon, such as immune exhaustion, leading to poor survival rates in these INV-H tumor samples.