This gene signature includes COL11A1, POSTN, EPYC, ASPN, COL10A1, THBS2, FAP, LOX, SFRP4, INHBA, MFAP5, GREM1, COMP, VCAN, COL5A2, COL5A1, TIMP3, GAS1, TNFAIP6, ADAM12, FBN1, SULF1, COL1A1 and DCN. While a pan-cancer analysis of invasiveness-associated dysregulated molecular features, including genomic, epigenomic, transcriptomic, proteomic, and metabolomic features, has been conducted in [4], the clinical impact of invasiveness for patient stratification and the mechanisms governing the transcriptional regulations and their associated pathway alterations are still poorly understood. This evidence concerns the gene COL1A1 and cancer.