This gene signature includes COL11A1, POSTN, EPYC, ASPN, COL10A1, THBS2, FAP, LOX, SFRP4, INHBA, MFAP5, GREM1, COMP, VCAN, COL5A2, COL5A1, TIMP3, GAS1, TNFAIP6, ADAM12, FBN1, SULF1, COL1A1 and DCN. While a pan-cancer analysis of invasiveness-associated dysregulated molecular features, including genomic, epigenomic, transcriptomic, proteomic, and metabolomic features, has been conducted in [4], the clinical impact of invasiveness for patient stratification and the mechanisms governing the transcriptional regulations and their associated pathway alterations are still poorly understood. The gene discussed is DCN; the disease is cancer.