MAPK9 and neoplasm: On the other hand, down-regulated genes were enriched in terms related to various tumor-associated survival pathways (i.e. positive regulation of JUN kinase activity, tRNA methylation, regulation of JUN kinase activity, regulation of phosphatidylinositol 3 − kinase activity, replication fork processing and positive regulation of MAP kinase activity; Fig. 2E and Additional file 6: Supplementary Table 5).