In tumors including nasopharyngeal carcinoma, lung cancer, hepatocellular carcinoma, and squamous cell carcinoma of the head and neck, METTL1 is able to mediate tRNA m7G modifications that regulate the translation process and ultimately lead to tumor progression [7, 8, 22, 27, 28]. The gene discussed is METTL1; the disease is nasopharyngeal carcinoma.