T2D is the most common type of diabetes mellitus in adults, for which there is no cure, and as a lifelong metabolic disease, lifestyle interventions while receiving oral hypoglycemic agents and insulin therapy can help achieve remission of T2D (blood glucose can still be in compliance or normal without the use of hypoglycemic agents), which is important to improve the psychological, physical, social, and economic stress of patients [16, 17]. Here, INS is linked to metabolic disease.