Model 3: Further adjustment from model 2 was made for duration of diabetes (≤ 3year,3–10year, or > 10 years), diabetes medication use (none, oral medication only, insulin, or other), glycated hemoglobin (< 7.0% or ≥ 7.0%), and self-reported hypertension (yes or no). The gene discussed is INS; the disease is diabetes mellitus.