The functional analysis of 514 proteins led to the identification of 11 salivary proteins characteristic of HPV associated oral cancer (RPRD2, PSCA, MCM2, MCM5, CDKN2A, BAK1, HSPA1A, HSPA5, HSPA8, TANK, MAP2K1). This evidence concerns the gene RPRD2 and lip and oral cavity carcinoma.