The functional analysis of 514 proteins led to the identification of 11 salivary proteins characteristic of HPV associated oral cancer (RPRD2, PSCA, MCM2, MCM5, CDKN2A, BAK1, HSPA1A, HSPA5, HSPA8, TANK, MAP2K1). The gene discussed is HSPA1A; the disease is lip and oral cavity carcinoma.