CRS mice treated with D4 also showed a significant decrease in the number of Iba1+ microglia (Control/vehicle, 100.0 ± 39.0%; CRS/vehicle, 303.9 ± 37.6%; CRS/D4, 160.3 ± 16.5), and a tendency to reduce CBF uptake in the Iba1+ microglia (Control/vehicle, 100.0 ± 31.4%; CRS/vehicle, 417.2 ± 58.6%; CRS/D4, 347.8 ± 57.6) in the hippocampal DG (Fig. 5D–F). Here, AIF1 is linked to congenital rubella syndrome.