We also found no significant association between genetically determined resistin concentrations and risk of CRC when restricting the analysis to cis-QTLs or trans-QTLs and applying the IVW method (IVW-ORper SD of resistin, cis-QTLs, 0.98 (95% CI 0.92, 1.04) and IVW-ORper SD of resistin, trans-QTLs, 1.07 (95% CI 0.98, 1.17), or other robust methods (e.g. results from the MR Egger method were not different from the IVW estimates and all p values for intercepts of the MR-Egger regression > 0.05) (Fig. 2, Supplementary Table 1). This evidence concerns the gene RETN and colorectal carcinoma.