Furthermore, it is notable that in our previous prospective study, we found a significant association of circulating resistin concentrations with risk of CRC in participants diagnosed within 2 years after blood sampling and their matched controls [RR 4th vs 1st quartile of resistin concentrations, 1.97 (95% CI 1.06, 3.64)], whereas no significant association was found in participants diagnosed with CRC after more than 2 years of blood sampling and their matched controls [RR 4th vs 1st quartile of resistin concentrations, 1.44 (95% CI 0.97, 2.12)] (Pham et al. 2022). Here, RETN is linked to colorectal carcinoma.