In the MR analysis using single-variant, we found a significant association between resistin and CRC risk when only the trans-pQTL rs2239619 was used as an IV, but not other pQTLs (Fig. 2).In the sensitivity analysis, by using “the partially independent cis-pQTLs”, we included eight variants including rs10401670, rs2161490, rs34124816, rs35547567, rs3745367, rs4804766, rs62110711, and rs77509849 as IVs. This evidence concerns the gene RETN and colorectal carcinoma.