NLRP3 and gout: Interestingly, the mechanosensitive Transient Receptor Potential Vanilloid 4 (TRPV4) channel, which is highly expressed by synovial macrophages of mice injected with MSU-crystals and peripheral blood mononuclear cells (PBMCs) from gout patients, may mediate NLRP3 inflammasome activation by endogenous and exogenous crystalline materials, including MSU crystals [46].