Another group looked at the effects of Celastrol, a pentacyclic triterpenoid used in traditional Chinese medicine, and showed that it alleviated MSU-induced gouty arthritis in mice by inhibiting NLRP3 inflammasome assembly by blocking BRCA1-BRCA2-containing complex subunit 3 (BRCC3) mediated K63 deubiquitination of NLRP3 [31]. The gene discussed is NLRP3; the disease is gout.