Additionally, Ero1α silencing could restore the protein levels of VE‐cadherin, p‐eNOS and eNOS in SIRT6‐deficient HUVECs under OGD/R conditions (Figure 3G), which suggested that inhibiting Ero1α could substantially ameliorate OGD/R‐induced endothelial dysfunction in the absence of SIRT6. Here, CDH5 is linked to endothelial dysfunction.