We evaluated the effects of targeting different molecules in VEGF signalling by gene editing tool after wet‐AMD onset and found that only an early intervention of Vegfa at the neoangiogenic phase of CNV could effectively suppress the angiogenesis in a short time with a reduction of VEGF protein by 63.2% and the CNV area by 49.5% (Figure 3), while intervention of Hif1α and Vegfr2 did not show significant therapeutic effect. The gene discussed is HIF1A; the disease is age-related macular degeneration.