YTHDF1 and neoplasm: The relationship between YTHDF1 and eIF3 contribute to the link of YTHDF1 with the translation initiation complex and YTHDF1 can bind to specific m6A sites locateing at 3′UTRs, coding regions and 5′UTRs of mRNA to promote translation [54]. According to the Oncomine database, YTHDF1 was highly expression in tumors and it overall expression level was strong correlation with survival prognosis, tumor mutational burden (TMB), immune checkpoints (ICP), microsatellite instability (MSI) and neoantigens formation.