The hepatocytes from CLD livers expressed significantly increased levels of PPARα (p = 0.0193), but decreased levels of FXR (p = 0.008), PXR (p = 0.0280), and MRP2 (p = 0.0193), when compared to controls (Figure 2). Here, NR1H4 is linked to congenital secretory chloride diarrhea 1.