NLRP3 and Salmonella Infections: Flagellin is involved in both NLRC4- and NLRP3-dependent pyroptosis induction in Salmonella infection.41 We constructed a fliC mutant in AC047 to determine if the absence of fliC affected cytotoxicity in AC047 infection of NLRC4 KO or NLRP3 KO THP-1.