RB1 and mantle cell lymphoma: On the contrary, CDKN1C loss in erdafitinib treated cells failed to up-regulate the expression of KDM2B, suggesting that its regulation may be Rb-E2F independent, possibly through EZH2, as ectopic expression of EZH2 restored the expression of KDM2B in erdafitnib treated MCL cells (Fig. 5F).