In summary, our data provide a model of cellular proliferation in MCL that is dependent upon FGFR1 levels and shows that FGFR1 loss up-regulates the expression of CDKN1C via MYC/KDM2B/EZH2 axis and regulates E2F target gene expression such as CDK1, which forms a feedback loop to maintain MYC levels and provide a proliferative advantage to MCL cells (Fig. 7C). Here, CDKN1C is linked to mantle cell lymphoma.