EZH2 and mantle cell lymphoma: Since there are no specific KDM2B inhibitors, we performed transient knockdown of both KDM2B and EZH2 and found restoration of CDKN1C (Fig. S5C), similar to inhibition of EZH2, confirming a role of KDM2B and EZH2 to repress the expression of CDKN1C in MCL cells.