Since FGFR1 loss downregulates the expression of both KDM2B and EZH2, we asked a) if loss or inhibition of FGFR1 in MCL can restore the expression of CDKN1C and b) if restoration of CDKN1C is needed for a high percentage of G1 Phase cells in MCL. The gene discussed is KDM2B; the disease is mantle cell lymphoma.