As shown in Fig. 5D, transactivation of the representative bona fide E2F1 target genes (CDK1, TK1, UHRF1, PCNA, TUBA1B [51–54]), which are also part of the PSG in MCL, were down-regulated in shFGFR1 cells. The gene discussed is TUBA1B; the disease is mantle cell lymphoma.