EGF and neoplasm: In glioma, the presence of MFG-E8 (Milk fat globule EGF factor) derived from tumor cells promotes the ITGB3/STAT3 pathway, which leads to increased secretion of IL-4, ultimately resulting in the differentiation of microglia into a pro-tumor phenotype and upregulation of molecules such as TGF, IL-10, and CD206.