NLRP3 and familial cold autoinflammatory syndrome: Gain-of-function point mutations that confer constitutive activation of NLRP3 have been identified as the cause of the three syndromes that comprise the CAPS family: familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), and neonatal onset multisystem inflammatory disease (NOMID), which have overlapping symptoms of fever, rash and arthralgia but differ in terms of severity, organ manifestations and environmental triggers12–14.