NLRP3 has been linked to the pathophysiology of rheumatoid arthritis (RA)16,17, systemic lupus erythematosus (SLE)18–20, gout17,21, nonalcoholic steatohepatitis (NASH)22–25, Alzheimer’s disease (AD)17,26,27, multiple sclerosis (MS)28–33, atherosclerosis17,34,35 and asthma and airway inflammation36–38. This evidence concerns the gene NLRP3 and asthma.