NLRP3 has been linked to the pathophysiology of rheumatoid arthritis (RA)16,17, systemic lupus erythematosus (SLE)18–20, gout17,21, nonalcoholic steatohepatitis (NASH)22–25, Alzheimer’s disease (AD)17,26,27, multiple sclerosis (MS)28–33, atherosclerosis17,34,35 and asthma and airway inflammation36–38. Here, NLRP3 is linked to Alzheimer disease.