This is the case of NC_012920.1:m.10161 A > C19, (YP_003024033.1:p.Thr35Pro), which is located in the MT-ND3 loop (residues 24–54) and is contiguous to the m.10158 T > C (p.Ser34Pro) common variant, reported as “confirmed” by MITOMAP, as “pathogenic” in ClinGen, and is associated with Leigh disease or MELAS syndrome. Here, MT-ND3 is linked to Leigh syndrome.