In addition, FOXM1 activity is induced by the phosphorylation of multiple sites in its C-terminal domain by cell cycle-related protein kinases during mitosis, such as CDK1 [30] and PLK1 [40], which are essential protein kinases in G2/M phase to stimulate cell cycle progression and are considered as therapeutic targets in various cancers [43]. The gene discussed is FOXM1; the disease is cancer.