Humans with a homozygous loss-of-function mutation in OTULIN develop OTULIN-related autoinflammatory syndrome (ORAS), a potentially fatal, TNF-driven autoinflammatory disease characterized by severe systemic inflammation, recurrent fevers, panniculitis, and arthritis, but also with diarrhea [9, 10, 12], suggesting a role for OTULIN in intestinal homeostasis. The gene discussed is TNF; the disease is arthritic joint disease.