PITX2 and esophageal squamous cell carcinoma: Paired-like homeodomain transcription factor 2 (PITX2) is a downstream effector of Wnt/β-catenin signaling, and inhibition of PITX2 expression and knockdown of its levels triggered more apoptosis, which in turn, significantly enhanced the sensitivity of ESCC cells to IR and cisplatin but appeared to be unrelated to EMT [143].