For example, the c-Met inhibitor BPI-9016 M was used to assess its radiosensitizing potential in human ESCC cells in vitro and in vivo, and the results showed that the combination of BPI-9016 M with IR significantly retarded the growth of ESCC tumor xenografts by inhibiting DNA HR repair compared to RT alone [74]. The gene discussed is MET; the disease is esophageal squamous cell carcinoma.