Yang et al. [87] demonstrated that M2 polarization increased PD-L2 expression in TAMs and then activated the PD-1 signaling pathway to promote tumor proliferation; blocking the CCL2-CCR2 axis impeded TAM recruitment, thereby enhancing the anti-ESCC efficacy of CD8 T cells. The gene discussed is CD8A; the disease is esophageal squamous cell carcinoma.