Heat shock factor (HSF)-1 supports macrophage production by inducing increased expression of HIF-1, which may be essential in the formation of M2-like TAMs in response to inflammatory stress [82], and the formed M2-like TAMs mainly exert anti-inflammatory and tumor-promoting effects [83]; therefore, macrophages recruited into the TME are thought to be polarized from the M1 subtype to the M2 subtype [84], and high doses of radiation are one of the factors that promote this polarization. Here, HIF1A is linked to neoplasm.