Naomichi Koga et al. [88] reported that signal regulatory protein alpha (SIRPα) may induce immunosuppression by inhibiting TAM phagocytosis and that coexpression of SIRPα and PD-L1 is significantly associated with ESCC infiltration and has a worse prognosis than patients expressing the proteins alone or expressing neither. This evidence concerns the gene SIRPA and esophageal squamous cell carcinoma.