Neural precursor cell expressed developmentally downregulated 9 (NEDD9) acts as a marker of ESCC, regulates CXCL8 through the ERK pathway, recruits MDSCs into tumor tissue, and maintains ESCC cell stemness through the Notch pathway, which in turn enhances the radioresistance of cancer cells [95]. This evidence concerns the gene CXCL8 and esophageal squamous cell carcinoma.