Xia et al. [60] reported that Nrf2 targets Ca2+/calmodulin-dependent protein kinase II α (CaMKIIα) by inhibiting mTOR and p62 phosphorylation, activating Beclin 1 and subsequently activating autophagy to promote ESCC radioresistance. This evidence concerns the gene NFE2L2 and esophageal squamous cell carcinoma.