Phosphorylation of FMS-related tyrosine kinase 3 (Flt-3) receptor increased significantly by FMS-related tyrosine kinase 3 ligand (FL) after irradiation (IR), further activating the PI3K/AKT/BAD signaling pathway, promoting clone formation and enhancing DDR and inhibiting IR-induced ESCC apoptosis through upregulation of p-Bad anti-apoptotic protein (Ser136 protein) [18]. The gene discussed is AKT1; the disease is esophageal squamous cell carcinoma.