The ADNI study, represented in TADPOLE, recorded a total of 1737 participants with a diagnosis at baseline together with their demographic information (age, sex, and education), behavioral information (smoking and alcohol abuse history), clinical measurements (BMI, FDG-PET imaging, brain volumetric measurements with MR imaging, Aβ and tau protein concentrations in cerebrospinal fluid (CSF), Minimental State Cognitive Exam (MMSE)) and medical history (history of hypertension and cardiovascular events) (Table 2). Here, MAPT is linked to alcohol abuse.