In addition, Nobiletin conquered AD through several mechanisms including anti-oxidant, anti-inflammatory (Nakajima and Ohizumi 2019), enhancing autophagy through SIRT1/FoxO3a pathway, cognitive and behavioral preservation, halting cholinergic neurodegeneration as well as Aβ pathology, and tau hyperphosphorylation. The gene discussed is SIRT1; the disease is Alzheimer disease.