Insufficiency of the crucial autophagy-related gene 5 (ATG5) or ATG7, especially in the central nervous system, resulted in accelerated irregular intracellular protein accumulation, neuronal degeneration, and an incredible amount of tau proteins aggregates, all of which add value to the late onset of many neurodegenerative diseases, which include AD (Hara et al. 2006). The gene discussed is MAPT; the disease is Alzheimer disease.