AKT1 and Alzheimer disease: STZ injection in the current experiment showed augmented phosphorylation of Akt, an effect that was reported in past studies indicating that brain autophagy was dampened in STZ-treated mice (Bordone 2005; Agrawal et al. 2011) On the other hand, Nobiletin depressed the level of p-Akt (Ser473), as previously mentioned (Chen et al. 2014; Lee et al. 2011), and thus stimulating autophagy and halting the progression of AD.