ANXA3 and cancer: ANXA3 is aberrantly expressed in various kinds of tumors and shows an association with cancer progression.23 The elevated ANXA3 level in osteosarcoma and its correlation with cell apoptosis have been reported.6 To investigate the function of ANXA3 in OS, we herein measured ANXA3 expression in OS cells by means of RT-qPCR and found an increasing trend of ANXA3 expression (Fig. 2A).