Furthermore, deficiencies in urate handling in the PT have been associated with exercise-induced acute kidney injury with acute tubular necrosis: Loss of function of the apical URAT1 (SLC22A12) and basolateral GLUT9 (SLC2A9) transporters lead to kidney hypouricemia which can be aggravated by physical stress [62]. This evidence concerns the gene SLC2A9 and acute kidney injury.