Reasons for exclusion after review were: family history was of unclassified focal epilepsy (n = 7) or of other epilepsies (n = 89); family history of FS only (n = 46); family history was of an unknown/undefined epilepsy type (n = 156); family genetically solved with a pathogenic variant in NPRL2, NPRL3, or SCN1B (n = 5); or MTLE cases were more distant than second degree relatives (n = 32). This evidence concerns the gene NPRL3 and epilepsy.