From the intersection of the Lasso regression and Boruta feature selection algorithms, six key DEGs were identified: CIDEA, TKT, CGN, FSCN1, ECHDC3, and ANXA3. Additionally, we downloaded an obese T2DM-related dataset from the GEO public database along with the corresponding clinical data from GSE29231 to analyze differences in these key DEGs. The gene discussed is ANXA3; the disease is type 2 diabetes mellitus.