Moreover, previous studies described the involvement of the CSN in NF-κB activation in endothelial cells, myeloid cells, T cells, Hela cells, cardiomyocytes, cardiac fibroblasts, and MLN4924 was found to reduce NF-κB signaling in B cells, myeloid leukemia cells, cervical cancer cells, and macrophages [39]. Here, NFKB1 is linked to myeloid leukemia.