PLCG1 and cancer: Prior research indicated that the pyroptosis-related genes involve in the tumor immunity and have a prognostic value in ovarian cancer, that absent-in-melanoma-2 (AIM2) acts as a cancer-promoting gene in ovarian cancer, but in other cancers, AIM2 is a tumor suppressor; and the high expression of gasdermin A (GSDMA) and phospholipase C gamma 1 (PLCG1) in ovarian cancer was connected to poor survival in patients [23, 24].