Carcinogenic species participating in ROS formation may trigger overexpression of the phosphorylated epidermal growth factor receptor (EGFR) protein and its ligand amphiregulin (AREG) a widely expressed transmembrane tyrosine kinase which in turn promotes uncontrolled proliferation of lung adenocarcinoma cells (Kometani et al. 2009). This evidence concerns the gene AREG and lung adenocarcinoma.