2006). Chemopreventive properties of EGCG have been documented by inhibition of human gastric adenosquamous carcinoma mediated by the inhibition of matrix metalloproteinase induction (Onoda et al. 2011). EGCG as a chemopreventive agent can modulate angiogenesis and apoptosis by downregulation of various signaling pathways such as Vascular Endothelial Growth Factor (VEGF), Epidermal Growth Factor Receptor (EGFR) and cell cycle regulatory proteins such as Mitogen-activated protein kinases (MAPK) (Shankar et al. 2007). The gene discussed is VEGFA; the disease is gastric adenosquamous carcinoma.