In terms of tumor tissues, pancreatic cancer, head and neck cancer, skin cancer, urothelial cancer, cervical cancer, and stomach cancer showed moderate to strong cytoplasmic and/or membranous staining of RHOV, whereas RHOV staining was negative for glioma, carcinoid, renal cancer, prostate cancer, endometrial cancer, and lymphoma (Fig. 3B). This evidence concerns the gene RHOV and central nervous system cancer.