To further assess the effects of surgical approaches on the RFS of BCLA 0‐A HCC patients with PIV‐APF status 4, we conducted multivariate analysis using cox regression model, the results suggested that LH remained a marginal risk factor for the RFS (HR: 1.5846, p = 0.0564) while MVI positivity showed the strongest predictive ability to inferior RFS (Table S1). The gene discussed is PLOD1; the disease is hepatocellular carcinoma.