AFP and hepatocellular carcinoma: Firstly, this was so far the largest single‐center cohort in assessing the prognostic value of PIVKA‐II to HCC patients, including 518 histologically diagnosed participants, another large multicenter cohort (1194 participants) reported by Yang et al mainly focused on the diagnosis of HCC in patients with chronic hepatitis B (CHB)41; the proposed PIV‐AFP status also showed optimal effectiveness in predicting long‐term outcome.