To further reduce the potential selection bias of this retrospective study, a propensity score‐matched analysis was conducted, 23 patients in LH group and 57 patients in OH group were included (Table 4), after propensity score matching, the BCLC 0‐A HCC patients with PIV‐AFP status 4 underwent LH still presented marginal significantly declined RFS compared with those underwent OH (Figure S1). The gene discussed is AFP; the disease is hepatocellular carcinoma.