The expression of EZH2, AURKA or TK1 was knocked down in PCa cells (Figure S3a), and CCK-8 assays (Fig. 6a and b), EdU assays (Fig. 6c, d and S3b) and colony formation assays (Fig. 6e and f) were performed to assess cell viability. Here, EZH2 is linked to posterior cortical atrophy.