Taken together, the above data indicated that SNHG4 modulates the cell proliferation, cell cycle and DNA damage response of PCa cells by regulating RRM2 via a let-7 miRNA-mediated ceRNA network, and the expression of RRM2, EZH2, AURKA and TK1 was altered in accordance with SNHG4 knockdown. Here, AURKA is linked to posterior cortical atrophy.