ESR1 and familial pancreatic carcinoma: Interestingly, using scRNA-seq references from pancreatic and breast tissues of healthy individuals is also sufficient to identify the cell type of origin for all subtypes in pancreatic cancer (Additional file 1: Fig. S22), as well as the basal origin of basal subtype and the luminal origin of ER + breast cancer (Additional file 1: Fig. S24).