TRPV4 and Hydrocephalus: In Fig. 4 we demonstrate that neither hydrocephalus nor SI113 treatment modify transcriptional levels of Sgk1 or Trpv4. We established that neither hydrocephalus nor SI113 treatment modify abundance of the TRPV4 protein in the choroid plexus (Fig. 5), similar to our previous study in which TRPV4 antagonists were shown to ameliorate hydrocephalic development [20].