In order to investigate the effects of PCMT1 on tumor growth and the tumor immune microenvironment, we further studied the role of PCMT1 in vivo by establishing a mouse model of liver cancer, we found that the tumor volume grew more slowly, and the apoptotic staining and caspase-3 expression were significantly higher in the tumor area in the knockdown group, suggesting that knockdown PCMT1 may promote the necrosis and apoptosis of tumor tissue. Here, PCMT1 is linked to neoplasm.