CASP3 and neoplasm: In order to investigate the effects of PCMT1 on tumor growth and the tumor immune microenvironment, we further studied the role of PCMT1 in vivo by establishing a mouse model of liver cancer, we found that the tumor volume grew more slowly, and the apoptotic staining and caspase-3 expression were significantly higher in the tumor area in the knockdown group, suggesting that knockdown PCMT1 may promote the necrosis and apoptosis of tumor tissue.