CD4 and cancer: Therefore, we further tested the infiltration of CD4+ and CD8+T cells in the tumor area, and found that knockdown of PCMT1 significantly increased the infiltration of CD8+T cells, Activation of CD8+T cells is often considered a key factor in cancer immunotherapy [37], although we did not observe significant changes in CD4+T cells, further subgroup analysis, such as whether there are changes in Treg cells, is also worth further investigation.