CD19 and neoplasm: In a phase 1/2 clinical trial, Singh et al. produced CD19-targeting CAR-T cells with a CAR-positive rate of over 90% using the SB11 transposon, and these cells demonstrated powerful anti-tumor effects [443] However, when Jin et al. compared the transposition activity of SB11 and SB100X, they discovered that SB100X was roughly 3.6 times more effective than SB11 at producing CAR-T cells, indicating that the potential of SB system in T cell editing has yet to be fully explored [444].