Through research using RAW264.7 cells, Zhu et al. discovered that employing Mer receptor tyrosine kinase (MerTK) as the intracellular domain confers macrophages with potent phagocytic abilities toward tumor cells, whereas using TLR2, TLR4, TLR6, and CD3ζ had relatively little effect [378]. This evidence concerns the gene MERTK and neoplasm.