In addition to CAR-mediated cytotoxicity, γδT cells can also recognize tumor cells through intrinsic receptors (Vδ1TCR, CD16, NKG2D, and NKp30) and activate various natural tumor-killing pathways, such as perforin/granzyme-dependent cytotoxicity, CD16-mediated ADCC, and TRAIL/FASL-triggered apoptosis [382] (Fig. 7A). Here, PRF1 is linked to neoplasm.