EIF4EBP1 and cancer: Interestingly, third-generation bi-steric mTORi can drive cancer regression more significantly than ATP-competitive mTORi, due to their potent and selective inhibition of 4E-BP1 phosphorylation, while minimizing adaptive resistance due to the relief of feedback inhibition of RTK expression and signaling, as well as undesirable toxicity and glucose intolerance [369].