PIK3CB and neoplasm: Indeed, a GSK3-associated signaling transduction pathway that is often involved in human tumor is the EGFR/Ras/PI3K/PTEN/AKT/GSK3/mTORC1 axis, which exerts an important role in natural cell growth, and is frequently overactivated with mutations mainly occurring in PI3K (PIK3CA), Ras, and PTEN [136].