EIF4E and cancer: In turn, AKT hyperactivation in cancer cells brings further dysregulation in various epigenetic players participating in the PAM pathway, such as DNA maintenance methyltransferase DNMT1 [194], histone acetyltransferase CBP/p300 complex [195], histone H3K27 methyltransferase EZH2 [196], and histone H3K4 methyltransferase and demethylase KMT2D and KDM5A, respectively [31].