GPT and B-cell chronic lymphocytic leukemia: In CLL/SLL patients only, grade ≥ 3 immune-related toxicities consist of colitis (12%), pneumonitis (3%), increased alanine aminotransferase (ALT) (3%), and enhanced aspartate transferase (AST) (3%); in addition, the most frequently reported serious adverse event is pneumonia (15%) [251].