Furthermore, EVs carry pathogenic protein aggregates and are able to spread neurodegeneration-associated protein aggregates throughout the brain [100], such as Aβ [40] and tau in AD [41, 102], α-synuclein in PD [42, 44], TAR DNA-binding protein of 43 kDa (TDP-43) in amyotrophic lateral sclerosis [43], and huntingtin protein in Huntington's disease [103]. Here, MAPT is linked to Parkinson disease.