In patients with colon cancer, F. nucleatum activates the transcription of long noncoding RNA (lncRNA) ENO1 Intronic Transcript 1 (ENO1-IT1) by up-regulating the binding efficiency of transcription factor SP1 to the promoter region of lncRNA ENO1-IT1 and promoting glucose metabolism in CRC cells to induce cancer [146]. This evidence concerns the gene SP1 and malignant colon neoplasm.