A low-calorie, low-protein, low-carbohydrate HFD was adopted as a fast-mimicking diet; this diet may promote cell regeneration by reducing the activity of protein kinase A and mTOR, inducing the expression of Sox2 and Ngn3, and restoring insulin generation, secretion, and glucose homeostasis in T2D mouse models and T1D patients [233]. The gene discussed is INS; the disease is type 2 diabetes mellitus.