The critical role of the EMT process in PTX resistance, [83], is well represented indicated by the resistance and sensitivity marker panel we identified in BC-PDMs, including EMT-regulator proteins such as Vimentin-pSer56, CK5, CK6, E-Cadherin, CK8/18, IKKα-pThr23, beta-Catenin-pSer55. The gene discussed is CHUK; the disease is breast cancer.