Further, our DigiWest® data confirmed protein signatures of TNBC-PDMs consistent with those in the literature, characterized by upregulated PI3K/Akt and MAPK/RTK signaling [53, 63, 64, 98] with overexpressed proteins associated with integrated stress response [99–102], higher relapse rates, mortality [64, 103, 104], tumor growth and EMT [29, 105–107]. Here, AKT1 is linked to neoplasm.