Despite the well-described effects of chronic low-grade inflammation, immune dysregulation, adipose tissue dysfunction, and effects of specific ART of resulting in increased insulin resistance, an atherogenic lipid profile, and pancreatic beta-cell dysfunction [17–20], we did not observe increased insulin resistance, beta-cell secretory dysfunction, and an abnormal lipid profile in our HIV-infected study population. This evidence concerns the gene INS and Insulin resistance.