DDX5 and lung cancer: Furthermore, the study from Zhao et al. found that (i) DDX5 promotes replication of influenza A virus (IAV) in lung cancer A549 cells by its N terminus to interact with IAV’s nucleoprotein (independent of RNA) (Fig. 5E); and (ii) DDX5 suppresses antiviral innate immunity induced by IAV infection (Fig. 5E).