In this regard, it was recently demonstrated by Cheng et al. that UCP2 expression in melanoma is associated with elevated T cell infiltration in patient melanoma tumors and prolonged patient survival rates, and is associated with antitumor immune states in TME as well as conventional type 1 dendritic cells (cDC1) and CD8 + T cell infiltration in tumors [80, 81]. This evidence concerns the gene UCP2 and melanoma.