Ma et al. reported that DDX5 is a negative regulator of the retinoic acid-receptor (RAR)-related orphan receptor γ t (RORγt)-expressing regulatory T cells (RORγt + Tregs) suppressor activities [68], and that loss of DDX5 unleashes IL-10 production potential and suppressor activity in RORγt + Treg and protects against weight loss and pathology in murine models of T cell–mediated intestinal inflammation (Fig. 3D1) [68]. Here, DDX5 is linked to inflammatory response.