CD8A and cancer: The other 3 major findings by Liu et al.’s analyses include (i) methylation in the DDX5 promoter is significantly reduced in 8 cancer types [111]; (ii) DDX5 is associated with multiple cellular pathways (e.g., RNA splicing, Notch signaling, and viral carcinogenesis) [111]; and (iii) DDX5 mRNA expression is highly correlated with the infiltration of CD8( +) T cells, cancer-associated fibroblasts (CAFs), and B cells in a wide variety of malignancies [111].