DDX5 and neoplasm: Consistent with the previous observation that intestinal tumorigenesis in Apcfl/+Cdx2Cre+ mutant (APCΔcIEC) mice is driven by colonic immune cell–mediated inflammation [112], studies from Abbasi et al. revealed that DDX5 was expressed at a significantly higher level in colonic tumors from APCΔcIEC mice than adjacent normal tissues or IECs isolated from non–tumor-bearing WT Apc mice [69].