Consistent with the finding that RGG motif-methylated DDX5 is required for its interaction with XRN2 [29], Kang et al. found that the thyroid hormone receptor-associated protein 3 (Thrap3) plays a causal role in promoting R-loop resolution via interaction with methylated DDX5 localized to R-loops in cancer cells [31]. This evidence concerns the gene THRAP3 and cancer.