For example, in regard to DDX5 acting as a transcription co-activator to upregulate the expression of different genes in the case of DDX5 in resolving G-quadruplexes (G4) structure for transcription, Wu et al. reported that DDX5 is extremely proficient at unfolding a DNA G4 structure in the Myc proximal promoter region (MycG4 that functions as a transcriptional silencer) to turn on the Myc oncogene expression in breast and prostate cancer [55]. The gene discussed is MYC; the disease is prostate cancer.