Their studies revealed that the E3 ligase β-Trcp interacts with and degrades DDX5, which could be blocked by CSN6 via inhibiting ubiquitin–proteasome-mediated protein degradation to stabilize DDX5 protein and in turn promote DDX5-mediated PHGDH mRNA stabilization, leading to metabolic reprogramming in CRC cells and in turn, the CSN6-DDX5-PHGDH axis promotes tumorigenesis and is associated with poor CRC patient prognosis (Fig. 4D) [85]. This evidence concerns the gene COPS6 and colorectal carcinoma.