DDX5 involves diverse oncogenic signaling pathways including cancer-controlled gene expression, various RNA metabolism, DNA repair and R-loop resolution during DNA replication and transcription (Figs. 1 and 2), immune suppression (Fig. 3), cancer metabolic control (Fig. 4), virus infection promotion (Fig. 5), and microbiota negative influence (Fig. 6). This evidence concerns the gene DDX5 and viral infectious disease.