Consistent with the findings from the drug target MR analyses mentioned earlier, the SMR analyses showed that higher expression level of PCSK9, APOB, and LPL was associated with a lower risk of migraine, while higher expression of HMGCR, ABCG5/ABCG8, and CETP could contribute to a higher risk of migraine. The gene discussed is PCSK9; the disease is migraine disorder.