A transient increase in the proinflammatory cytokine ICAM-1 and chemokine levels has been confirmed in the jugular blood of migraine patients during attacks [91] and intracranial inflammatory plasma extravasation ipsilateral to the side of headache has been demonstrated with Tc-99 m human serum albumin tracer extravasation in the area of pain [92] as well as gadolinium enhancement close to the middle meningeal artery [93]. The gene discussed is ICAM1; the disease is migraine disorder.